Synthesis of 5-Thio-L-Fucose and its Inhibitory Effect on Fucosidase
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 9 (5) , 683-694
- https://doi.org/10.1080/07328309008543863
Abstract
5-Thio-L-fucose was synthesized for the first time from D-glucose in 16 steps and -found to have a remarkable inhibitory effect on fucosidases from bovine epididymis (Ki 4.2x10−5 M) and kidney (Ki 8.4 x 10−5 M).This publication has 8 references indexed in Scilit:
- Glycosidase inhibition by plant alkaloids which are structural analogues of monosaccharidesPhytochemistry, 1985
- Further stereoselective reductions of 3-O-hexofuranosyl S-methyl dithiocarbonates with tributyltin deuteride. A comment on mechanismAustralian Journal of Chemistry, 1980
- Synthesis of 5-thio-D-galactoseCarbohydrate Research, 1979
- Synthesis of 2-acetamido-2-deoxy-5-thio-d-glucopyranoseCarbohydrate Research, 1978
- 5-thio-l-rhamnoseCarbohydrate Research, 1977
- 5-Thio-D-fructofuranoseThe Journal of Organic Chemistry, 1975
- Derivatives of α-D-Glucothiopyranose1The Journal of Organic Chemistry, 1966
- 211. Some carbohydrate episulphidesJournal of the Chemical Society, 1960