Effect of Irradiation and of Various Reagents on Viscosity of Nucleoprotein Solutions.

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Abstract
Cysteine, glutathione, cyanide, and thiocyanate greatly increase the viscosity of alkaline solns. of nucleoprotein (thymus chromosomes), while urea, uracil, thiourea, thiouracil, cystine, and BAL do not do so. Ascorbic acid increases the viscosity only after prolonged incubation. H2O2 is without effect on the viscosity. If cysteine is added to the alkaline nucleoprotein soln. before X-radiation, the expected reduction in viscosity is largely prevented. If the cysteine is added after X-radiation, it is much less effective in this respect. The suggestion is made that these phenomena may be relevant to the question of the mechanism of cysteine and some other agents in increasing resistance of organisms to X-ray lethality.

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