In Vivo Effects of Prostaglandin F2α and E2 on Contractility and Diameter of the Rabbit Oviduct Using Intraluminal Transducers

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Abstract
Donut-shaped conductive Silastic micro-transducers were used to study the effects of i.v. administration of prostaglandin (PG) F2.alpha. and E2 on contractility and internal diameter of the oviductal isthmus in unanesthetized rabbits. The characteristic response to PGF2.alpha. was an abrupt increase in internal diameter and a concomitant increase in frequency of contractions. In a few animals there was no change in baseline diameter or only a gradual decrease in diameter. In all animals responding to PGF2.alpha. there was a consistent increase in frequency of contractions, but normally little increase in amplitude of contractions. Simultaneous cinematographic recordings during acute experiments indicated that abrupt increases in internal diameter were associated with contraction of longitudinal muscles and/or mesentery. The effect of epinephrine was similar to that of PGF2.alpha.. PGE2 blocked spontaneous activity of the longitudinal and circular muscles but produced little change in internal diameter. Responses to PGE2 was similar to that observed for isoproterenol. Measurement of contractility and internal diameter suggests that PGF2.alpha. increases the rate of egg transport by increasing oviductal diameter and increasing the rate of contractions. No change in diameter and blockage of spontaneous activity could explain why PGE2 has little effect on egg transport rates.

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