Biosynthesis of Dehydroepiandrosterone in a Patient with a Virilizing Adenoma

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Abstract
Pregnenolone-7α-H3 and cho lesterol-4-C14 were incubated with a homog enate prepared from a virilizing adrenal ade noma. Since dehydroepiandrosterone-H3-Cu14was formed, and since a metabolite of pregnenolone-7-H3 was detected which contained no C14, it appears quite likely that a portion of the dehydroepiandrosterone was formed from cholesterol by a pathway not involving pregnenolone. This conclusion is consistent with a previous in vivo study involving the same tumor and the same substrates administered intravenously.