Effects of Neoglycoproteins on Penetration of Plasmodium falciparum Merozoites into Erythrocytes In vitro

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Abstract
Sugars conjugated to bovine serum albumin (neoglycoproteins) were tested for their ability to inhibit P. falciparum merozoite invasion of [human] red blood cells in an in vitro inhibition assay. The inhibitory effects of the neoglycoproteins on merozoite invasion of erythrocytes were determined by assessing 3H-hypoxanthine incorporation into the cultures. The only neoglycoprotein that caused significant inhibition was N-acetyl-glucosamine-bovine serum albumin. A comparison of the inhibitory effects of N-acetyl-glucosamine and N-acetyl-glucosamine-bovine serum albumin showed that N-acetyl-glucosamine-bovine serum albumin was 84-fold more effective than the free sugar in causing 50% inhibition of 3H-hypoxanthine incorporation.