The adherence of Candida yeasts to human and bovine vascular endothelium and subendothelial extracellular matrix

1 December 1987

journal article
Published by Oxford University Press (OUP) in FEMS Microbiology Letters

Vol. 48 (1-2) , 201-205
https://doi.org/10.1016/0378-1097(87)90162-5

Abstract

The adherence of Candida albicans yeasts and other Candida species to human umbilical vein endothelial cells (HUVEC), bovine aortic endothelial cells (BAEC) and their respective subendothelial extracellular matrices (ECM) was studied. Yeast adherence to confluent HUVEC and BAEC appeared to occur at intercellular junctions and edges of endothelial cells in preference to the contoured surface of the endothelial cell. Both endothelial cell lines characteristically resisted yeast adherence. The resistance of endothelium to yeast adherence was especially pronounced in the presence of serum. On the other hand, there was avid yeast binding to the subendothelial ECMs, on the order of 200–500% greater than to monolayers of syngeneic endothelial cells.

Keywords

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