Angiography has revealed a high incidence of the clinical and pathologic syndrome of necrotizing angiitis in drug abusers. Positive evidence supported by 3 postmortem reports has been uncovered in 13 of 30 patients. Eight additional patients had angiographic changes of an equivocal nature. Angiitis of drug abuse has been added to the classification of necrotizing angiitis. The clinical and pathologic features of periarteritis nodosa and the angiographic patterns of necrotizing angiitis are presented.