Rm values and structure-activity relationship of benzodiazepines
- 1 February 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (2) , 193-201
- https://doi.org/10.1021/jm00176a016
Abstract
Quantitative structure-activity relationships (QSAR) were formulated for the activities of a series of benzodiazepines in rats. The lipophilic character of molecules was expressed by the chromatographic Rm values, which were very well correlated with experimental or calculated log P values. The ideal lipophilic character for activity of benzodiazepines in the exploratory behavior test is not far from that of compounds acting in the CNS as unspecific depressant agents. The results of the conflict and exploratory behavior studies might support the hypothesis of different sites of action for the antianxiety and sedative effects of benzodiazepines.This publication has 6 references indexed in Scilit:
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