Gastrointestinal Angiodysplasia and Aortic Stenosis

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Abstract
For unknown reasons, bleeding from gastrointestinal angiodysplasia in patients with severe aortic stenosis (Heyde's syndrome1) usually ceases after aortic-valve replacement.2 We have proposed that this bleeding disorder may be explained by acquired type IIA von Willebrand's syndrome,3 which is a deficiency of high-molecular-weight multimers of von Willebrand factor associated with aortic stenosis. We now report two cases of Heyde's syndrome in which abnormal von Willebrand factor–multimer profiles normalized after aortic-valve replacement.