Dual-action penems and carbapenems
- 1 May 1992
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 35 (10) , 1828-1839
- https://doi.org/10.1021/jm00088a019
Abstract
Two new series of dual-action antibacterial agents were synthesized in which penems and carbapenems were linked at the 2'-position to quinolones through either an ester or a carbamate moiety. Potent, broad-spectrum antibacterial activity was observed for both classes of compounds, indicative of a dual-mode of action.Keywords
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