Cytotoxicity of Lymphocytes in Experimental Alcoholic Liver Injury in the Baboon

Publisher Website
Google Scholar
Abstract
To study the role of immunologic reactions in the development of alcoholic liver disease, cytotoxic activity of lymphocytes against autologous liver grown in tissue culture was investigated. The experimental model was that of ethanol-fed baboons which develop the entire spectrum of alcoholic liver disease. Liver tissue was obtained at laparatomy in 12 animals given alcohol for 16-38 mo. and in 12 pair-fed controls. Lymphocytes of all alcohol-treated animals (but not of the controls) exhibited cytotoxicity against autochthonous liver cells; there was a marked decrease in the number of surviving cells and a significant reduction in their [3H]proline label.

This publication has 0 references indexed in Scilit: