Metal Ion Activation of Phosphate Transfer by Bidentate Coordination
- 18 April 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 164 (3877) , 320-321
- https://doi.org/10.1126/science.164.3877.320
Abstract
The hydrolysis of methyl phosphate bound to the triethylenetetramine-cobalt(III) ion is much faster than the hydrolysis of either dimethyl phosphate bound to the same cation or methyl phosphate bound to the pentamminecobalt-(III) ion. The rate enhancement is attributed to bidenate coordination of the methyl phosphate. This feature suggests a pseudorotation mechanism analogous to that proposed by Westheimer for the hydrolysis of ethylene methyl phosphate. Stabilization of bidentate coordination might play a role in metal ion activation of phosphate-transfer enzymes.Keywords
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