Increased Rate of Sealing in Beating Heart Muscle of the Toad

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Abstract
The influence of stimulation on the healing-over of myocardial cells of the toad was investigated. The rate of sealing was markedly increased in beating muscles. This effect of stimulation on the healing process varied with the frequency of the stimulus and depended on the extracellular Ca concentration. Low sodium solutions increased the rate of sealing in stimulated muscles but not at rest. Some evidence is presented that the increased Ca influx which accompanies stimulation activates the reactions involved in the sealing process.