Genetic Factors in Alzheimer's Disease

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Abstract
Nearly 100 years ago, Alois Alzheimer described the clinical and pathological characteristics of a 50-year-old woman with the dementing illness that now bears his name.1 She had no family history of dementia. It soon became established dogma that Alzheimer's disease was a rare, noninherited cause of presenile dementia.The past 25 years have seen an astounding confluence of seven new observations that have resulted in fundamental changes in our understanding of this important disease. First, Alzheimer's disease is by far the most common cause of dementia. Second, the major pathological component of the disease is the accumulation of a form . . .

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