PROGESTERONE AND OESTRADIOL IN PITUITARY, BRAIN AND UTERINE TISSUES OF THE SHEEP

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Abstract
The concentrations of 2 steroids, progesterone and estradiol, were compared in neuroendocrine and uterine tissues of ovariectomized sheep treated with physiological amounts of the hormones. Clear differences between the uptake and retention of progesterone and estradiol by different target tissues were demonstrated. Relative to the plasma concentration, estradiol is taken up and retained in the pituitary and uterine caruncles to a far greater extent than is progesterone. The concentration of estradiol in the caruncles (100- to 200-fold greater than plasma) is significantly greater than in the pituitary (40-fold greater than plasma). These differences probably result from a number of factors, including the concentrations of steroid receptors, the rate and extent of metabolism of the steroids or to variations in the lipid solubilities of the hormones in these different areas.

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