A Genetic Marker of Human IgE Heavy Chains, Em(1)

Publisher Website
Google Scholar
Abstract
A monoclonal anti-IgE antibody was obtained that reacted with some IgE myeloma proteins and with all but a few normal sera. Family studies proved that a genetic marker of IgE had been detected. This allotype, called Em(1), segregates in association with certain Gm-Am haplotypes. The available quantitative evidence warrants the conclusion that human IgE has genetic variants, but no subclasses. Samples from various populations of five continents, representative for the respective prevalent Gm-Am haplotypes, were tested for Em(1). Em(1) was absent mainly in haplotypes carrying A2m(2) and G2m(n). These closely linked genes are located in a chromosomal region that comprises the Y(2)-Y(4)-ε-α(2) CH genes. A hypothesis for the generation of Em(1) is given.

This publication has 0 references indexed in Scilit: