Assorbimento ed eliminazione biliare della rifamicina SV nell’uomo

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Abstract
Rifamycin-SV, administered at different doses and by different routes, is electively concentrated in the bile, where it reaches concentrations 2000 and more times higher than the blood levels. After intramuscular administration of 250-500 mg in cirrhotic patients, blood levels were significantly higher than in normal subjects. After the oral administration of 500 mg and 800 mg in normal subjects, the biliary excretion is so high that the antibiotic cannot reach the systemic circulation. In cirrhotic patients, the antibiotic may by-pass the liver and reach the systemic circulation, because of the special hemodynamic conditions of the portal system. After intravenous drip of 1 g of rifamycin-SV, in normal subjects, the biliary excretion of the antibiotic can be saturated. An initial simultaneous increase of both blood and biliary levels is followed by a further increase only in the former, when the stable concentrations around 2000-3000 [mu]g/ml are reached in the bile. Intramuscular and oral treatment with rifamycin-SV in subjects suffering from biliary infections was well tolerated and gave successful therapeutic results in all cases.

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