Percutaneous absorption of topically applied triamcinolone in children

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Abstract
The real and potential problems associated with the percutaneous absorption of topically applied corticosteroids were used as an argument against the prolonged administration of these drugs. Many pediatricians and dermatologists consider children to be more likely to absorb substantial quantities of topically applied corticosteroids than adults. This study examines the percutaneous absorption of 0.1% triamcinolone acetonide ointment applied 4 times a day for a period of 6 wk to patients with severe atopic eczema. The results of 8 a.m. and 4 p.m. plasma cortisol and 24 h urinary cortisol determinations do not indicate any notable adrenal suppression. No patient had an 8 a.m. cortisol value that would be considered in the abnormal range. The use of a medium-strength topical corticosteroid for this length of time probably poses no noteworthy hazard from percutaneous absorption.

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