HAND-MIRROR CELL LEUKEMIA ASSOCIATED WITH MENTAL-RETARDATION - IMMUNOLOGICAL, CHROMOSOME, AND MORPHOLOGICAL-STUDIES

  • 1 January 1979
    • journal article
    • research article
    • Vol. 54  (3) , 703-712
Abstract
Cytochemical, morphological, immunologic and cytogenetic studies were carried out on hand-mirror cells (HMC) from a mentally retarded patient with a constitutional chromosome abnormality, 46,XX,r(21), and acute lymphoblastic luekemia. Scanning electron and differential interference contrast microscopy showed microspikes on the uropodia, but little evidence of cellular motility, despite formation and disappearance of individual uropodia in cell suspensions. The cells rosetted with sheep erythrocytes, suggesting T[thymus-derived]-cell origin. Cells derived from the bone marrow (80% HMC) showed a high degree of polyploidy (60%) and a bimodal chromosome number of 49 (49,XX,+10,-21,+3 rings) and 94 (6 no. 10, 3 no. 18, 2 no. 21 chromosomes, 3 ring chromosomes, plus 4 copies of each other chromosome).

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