Glucose uptake in mouse brain regions under hypoxic hypoxia
- 1 September 1981
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 6 (9) , 993-1003
- https://doi.org/10.1007/bf00965030
Abstract
Glucose uptake of individual structures within the brain was studied by dry-autoradiography with 2-deoxy-D-[14C(U)]glucose under mild hypoxic hypoxia (12% O2∶88% N2 or 9% O2∶91% N2 for 1 hr). Glucose consumption in the whole brain was estimated by combined gas chromatography-mass spectrometry (GC-MS). Mild hypoxia increased the optical density of the autoradiograph in all regions. The deuterated G-6-P (Glucose-6-phosphate) synthesized from deuterated glucose decreased significantly with 9% O2 hypoxia (P2 hypoxia (P<0.01). The hippocampus, white matter, colliculus superior, and corpus geniculatum laterale appeared to be particulary sensitive to hypoxia.Keywords
This publication has 18 references indexed in Scilit:
- Alteration of acetylcholine synthesis in mouse brain cortex in mild hypoxie hypoxiaJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1981
- Local Cerebral Glucose Metabolism During Controlled Hypoxemia in RatsScience, 1979
- Autoradiographic maps of regional brain glucose consumption in resting, awake rats using [14c] 2‐deoxyglucoseJournal of Comparative Neurology, 1978
- RELATION BETWEEN PHYSIOLOGICAL FUNCTION AND ENERGY METABOLISM IN THE CENTRAL NERVOUS SYSTEMJournal of Neurochemistry, 1977
- The distribution of 14c from [U-14c]glucose in mice using whole-body autoradiography.Journal of Histochemistry & Cytochemistry, 1976
- Mass spectral study of cyclic alkaneboronates of sugar phosphates. Evidence of interaction between the phosphate group and boron under electron‐impact conditionsJournal of Mass Spectrometry, 1975
- INCORPORATION OF 14C FROM [U‐14C]GLUCOSE INTO FREE AMINO ACIDS IN MOUSE BRAIN REGIONS UNDER CYANIDE INTOXICATIONJournal of Neurochemistry, 1974
- INCORPORATION OF 14C FROM [U‐14C]GLUCOSE INTO FREE AMINO ACIDS IN MOUSE BRAIN LOCI IN VIVO UNDER NORMAL CONDITIONSJournal of Neurochemistry, 1973
- Brain Extracellular pH: The Main Factor Controlling Cerebral Blood FlowScandinavian Journal of Clinical and Laboratory Investigation, 1968
- Autoradiographic localization in the tissues of drugs and metabolitesBiochemical Pharmacology, 1962