Serum Proteolytic Enzyme Activity in Pancreatic Disease

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Abstract
RECENT reports have stressed the diagnostic value of measuring serum proteolytic activity in patients with pancreatitis and pancreatic carcinoma.1 2 3 4 Nardi,1 utilizing a synthetic substrate, benzoyl-l-arginine amide hydrochloride, observed an increase in serum proteolytic activity. This was initially considered due to an elevation of serum trypsin.1 , 2 Brown4 confirmed the finding of increased proteolytic enzyme activity in pancreatic disease by measuring the hydrolysis of a similar synthetic substrate, benzoy l-l-arginine ethyl-ester hydrochloride. He chose to describe this as arginine exopeptidase, noting that it represented nonspecific arginine-ester hydrolysis and not merely trypsin activity.This report concerns our observations of serum proteolytic activity in . . .

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