RELATIONSHIP OF BIOCHEMICAL AND MORPHOLOGICAL-CHANGES IN RAT THYROID AND PROTON SPIN-RELAXATION OF TISSUE WATER
- 1 January 1977
- journal article
- research article
- Vol. 69 (1) , 55-66
Abstract
Biochemical and morphological changes induced by antithyroid substances (PTU [propylthiouraclil] ClO-4) on proton spin-relaxation properties of rat thyroid gland were studied. Thyroid stimulated by PTU (0.05%) or ClO-4 (1.0%) exhibit morphological changes (hyperplasia and epithelial hypertrophy) with content and compositum alteration of the soluble iodoprotein pattern. Both relaxation times spin-lattice (T1) and spin-spin (T2) increased with the length of treatment with antithyroid drugs. Reversibility of the process was noted in accordance with biochemical and morphological data. The relaxation rate R1,2 = .**GRAPHIC**. for thyroid tissue water was positively correlated with the soluble protein concentration and particularly with the TG [thyroglobulin] content in the gland. There was no difference in relaxation times between normal thyroids and glands of rats treated chronically with excess I-. The observed difference in T1 between normal glands and glands of PTU,- ClO-4-treated rats was comparable with that found in cases of human thyroid cancer. A finding of importance when the diagnostic potential of NMR in the detection of malignancy is considered. A strong correlation was found between microstructural and biochemical changes of the thyroid gland and PMR of tissue water. The striking difference between the proton spin-relaxation times in normal thyroids and in thyroid glands of rats with goiter suggests that pulsed NMR spectroscopy could be a method for evaluation of some disturbances in thyroid gland.This publication has 0 references indexed in Scilit: