Cattle Biting Louse: Evaluation of Compounds for Juvenile Hormone Activity. 2. Hormonal and Toxic Effects13

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Abstract
Of 70 compounds related to the cecropia juvenile hormone that previously showed juvenile hormone activity against 1 or more species of insects, 4 (and also the standard) caused Bovicola bovis (L.) to retain nymphal characteristics in the 4th (normally adult) stage. These hormonally active compounds were 7, 8-epoxy-4, 8-dimethyl-1-m-tolylnonane; 8, 9-epoxy-5, 9-dimethyl-l-phenyl-2-decene; 5, 9, 13-trimethyl-4, 8, 12-tetradecatrien-3-onej 12, 13-epoxy-5, 9, 13-trimethyl-4, 8-tetradecadien-3-onej and the standard, methyl 10,11-epoxy-7-ethyl-3,11-dimethyl-2, 6-tridecadienoate mixed cis/trans isomers (a synthetic sample chemically equivalent to the male cecropia juvenile hormone). No exact relationship between hormonal activity and chemical structure could be established except that all active compounds had a chain of 9-14 carbons and that 3 of the 5 active compounds had 13 or 14 carbon atoms in the chain. Thirty-two compounds were toxic to B. bovis but did not show juvenile hormone activity.

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