Bmi1, stem cells, and senescence regulation
Open Access
- 15 January 2004
- journal article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 113 (2) , 175-179
- https://doi.org/10.1172/jci200420800
Abstract
Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.Keywords
This publication has 55 references indexed in Scilit:
- Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferationNature, 2003
- Identification of the haematopoietic stem cell niche and control of the niche sizeNature, 2003
- Osteoblastic cells regulate the haematopoietic stem cell nicheNature, 2003
- Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular SenescenceCell, 2003
- Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1Molecular and Cellular Biology, 2003
- Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role?Oncogene, 2002
- Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53The EMBO Journal, 1999
- Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivationOncogene, 1998
- Telomerase Activity in Hematopoietic Cells Is Associated with Self-Renewal PotentialPublished by Elsevier ,1996
- The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotypeImmunity, 1994