Serologic enzyme-linked immunosorbent assay responses of calves vaccinated with a killed Mycobacterium paratuberculosis vaccine

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Abstract
Summary The purpose of this study was to document the effect of calfhood vaccination for Mycobacterium paratuberculosis on a serologic elisa. Fifteen calves vaccinated with a killed paratuherculosis vaccine and 5 unvaccinated control calves were tested from the first through the fifteenth month of life. Age of vaccination ranged from 5 to 40 days. Blood samples were collected prior to vaccination and periodically thereafter. Serum antibody was analyzed by use of the elisa. All calves were elisa-negative prior to vaccination. Thirteen of 15 vaccinated calves became elisapositive between 2 and 6 months after vaccination. The unvaccinated cohort remained elisa-negative. Widespread use of vaccine may interfere with diagnosis of paratuberculosis and with control programs that are based 0n serologic tests that measure humoral antibody.

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