Long-term follow-up of MS: disease activity detected clinically and by MRI
- 1 September 1990
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 82 (3) , 191-196
- https://doi.org/10.1111/j.1600-0404.1990.tb04487.x
Abstract
Prospective clinical and magnetic resonance imaging (MRI) studies were performed over a period of 2-3 years on 51 MS patients. Comparing cerebral MRI and neurological evaluation for sensitivity in detecting disease activity, follow-up MRI turned out to be superior to standardized clinical assessment. In particular, an interval during which the clinical findings remain stable may not necessarily indicate that there is no florid inflammatory activity during this time. The morphological progression demonstrated a preference towards periventricular localization around the posterior horns of the lateral ventricles, and non-periventricularly in the frontal white matter. Longitudinal MRI studies of the disease activity can be an aid in obtaining a more definite diagnosis. Patients having had the disease for a longer period showed a more rapid clinical and morphological progression. Clinical progression and an increase in periventricular involvement were observed more often in the primary unremitting-progressive form of MS than in the relapsing-remitting form.Keywords
This publication has 21 references indexed in Scilit:
- Benign versus chronic progressive multiple sclerosis: Magnetic resonance imaging featuresAnnals of Neurology, 1989
- MAGNETIC RESONANCE IMAGING AND EARLY DIAGNOSIS OF MULTIPLE SCLEROSISThe Lancet, 1988
- Course and prognosis of chronic progressive multiple sclerosis: Results of an epidemiological studyActa Neurologica Scandinavica, 1988
- IMPORTANCE OF CRANIAL MAGNETIC RESONANCE IMAGING IN DIAGNOSIS OF MULTIPLE SCLEROSIS WITHOUT SUPRASPINAL SIGNSThe Lancet, 1988
- THE CHARACTERIZATION OF EXPERIMENTAL GLIOSIS BY QUANTITATIVE NUCLEAR MAGNETIC RESONANCE IMAGINGBrain, 1988
- Erstmanifestation der Encephalomyelitis disseminata: Kernspintomographische Verlaufskontrollen*Aktuelle Neurologie, 1987
- Magnetic resonance imaging in clinically isolated lesions of the brain stem.Journal of Neurology, Neurosurgery & Psychiatry, 1986
- The initial diagnosis of multiple sclerosis: Clinical impact of magnetic resonance imagingAnnals of Neurology, 1985
- Rating neurologic impairment in multiple sclerosisNeurology, 1983
- New diagnostic criteria for multiple sclerosis: Guidelines for research protocolsAnnals of Neurology, 1983