Blunted Prolactin Response to Thyrotropin-Releasing Hormone Stimulation in Cystinotic Children Receiving Cysteamine

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Abstract
We investigated whetherong term cysteaminetherapy in cystinotic children altered their basal and stimulatedserum PRL levels. Five subjects who had normal plasma PRLresponses to TRH stimulation before cysteamine treatment eachhad a lower basal PRL level and a blunted PRL response duringlong term (19–59 months) cysteamine therapy. A blunted PRLresponse was not found in 12 cystinotic subjects of the same ageand stage of disease who had not received cysteamine. The effecton PRL release was not found in 2 subjects who received shortterm (1–2 weeks) treatment with full-dose cysteamine (50 mg⁄kg day). The TSH response to TRH stimulation was not bluntedduring long term cysteamine therapy. These findings suggestthat cysteamine alters PRL secretion in humans.

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