Spontaneous Tumors in Aging (C57BL/6N X C3H/HeN)F1 (B6C3F1) Mice
Open Access
- 1 April 1988
- journal article
- research article
- Published by SAGE Publications in Toxicologic Pathology
- Vol. 16 (3) , 321-326
- https://doi.org/10.1177/019262338801600302
Abstract
Spontaneous tumors in untreated (C57BL/6N x C3H/HeN)F1 (B6C3F1) mice used as controls in carcinogenicity tests were recorded. In both sexes, the development of spontaneous tumors was age-related. In 244 male mice, the most common tumors were hyperplastic nodules of the liver, hepatocellular carcinomas, malignant lymphomas/leukemias, lung adenomas, and adenocarcinomas. In 246 female mice, the most common tumors were malignant lymphomas/leukemias, pituitary adenomas, neoplastic nodules of the liver, hepatocellular carcinomas, and lung adenomas. Hepatocellular carcinomas metastasized in 20.3% of the animals with these tumors. Few other tumors except malignant lymphomas and leukemias metastasized. Various tumors of other organs and/or tissues were found at low incidences.This publication has 6 references indexed in Scilit:
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