GROWTH AND CYTOGENETIC CHARACTERISTICS OF BONE-MARROW COLONIES FROM PATIENTS WITH 5Q- SYNDROME

  • 1 January 1985
    • journal article
    • research article
    • Vol. 66  (2) , 463-465
Abstract
Early erythroid precursor cells and myeloid progenitor cells (CFU-GM) from 4 patients with 5q- syndrome were cultured in order to study the in vitro growth patterns and to determine the clone origin of this hematologic disorder. Cultures of CFU-GM exhibited normal colony growth, while erythroid progenitor cells demonstrated a marked decrease or absence of colony growth. Chromosomal studies indicate the 5q- chromosome is present in both hematopoietic progenitor cells, suggesting that the syndrome is an acquired clonal disease arising from a pluripotent hematopoietic stem cell. Follow-up cytogenetic studies reveal a decrease in the number of normal metaphases. The slowly progressive nature of this malignant stem cell defect is emphasized.

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