Abstract
Hypoglycemia when associated with hyperinuslinemia is usually a consequence of an insulinoma or the administration of either insulin or an insulin secretagogue. Patients with hypoglycemia whose diagnosis was clarified by the use of a species-specific insulin radioimmunoassay are described. Of the 14 patients, 11 had elevated levels of animal insulin due to surreptitious accidental or malicious administration of insulin. Of the 14 patients, 3 had hyperinsulinemia as the result of excessive human insulin release and had either intrinsic pancreatic disease or secretagogue-mediated insulin release.

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