LOX-1 Mediates Oxidized Low-Density Lipoprotein-Induced Expression of Matrix Metalloproteinases in Human Coronary Artery Endothelial Cells
- 4 February 2003
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 107 (4) , 612-617
- https://doi.org/10.1161/01.cir.0000047276.52039.fb
Abstract
Background— Oxidized LDL (ox-LDL) accumulation in the atherosclerotic region may enhance plaque instability. Both accumulation of ox-LDL and expression of its lectin-like receptor, LOX-1, have been...Keywords
This publication has 18 references indexed in Scilit:
- Statins Modulate Oxidized Low-Density Lipoprotein-Mediated Adhesion Molecule Expression in Human Coronary Artery Endothelial Cells: Role of LOX-1The Journal of Pharmacology and Experimental Therapeutics, 2002
- Molecular Mechanism of the Induction of Metalloproteinases 1 and 3 in Human Fibroblasts by Basic Calcium Phosphate CrystalsJournal of Biological Chemistry, 2002
- Modulation of Matrix Metalloproteinase-1, Its Tissue Inhibitor, and Nuclear Factor-κB by Losartan in Hypercholesterolemic RabbitsJournal of Cardiovascular Pharmacology, 2002
- Statins inhibit oxidized-LDL-mediated LOX-1 expression, uptake of oxidized-LDL and reduction in PKB phosphorylationCardiovascular Research, 2001
- ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosisJournal of Clinical Investigation, 2001
- Upregulation of LOX-1 Expression in Aorta of Hypercholesterolemic Rabbits: Modulation by LosartanBiochemical and Biophysical Research Communications, 2000
- Identification and Autoregulation of Receptor for OX-LDL in Cultured Human Coronary Artery Endothelial CellsBiochemical and Biophysical Research Communications, 1998
- An endothelial receptor for oxidized low-density lipoproteinNature, 1997
- Vascular incorporation of alpha-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulation.Journal of Clinical Investigation, 1996
- Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.Journal of Clinical Investigation, 1994