Dwarfism with Elevated Levels of Plasma Growth Hormone

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Abstract
The elevated plasma levels of human growth hormone of two siblings with severe proportional dwarfism did not decrease after glucose administration and rose further on stimulation with arginine, hypoglycemia and Bovril. The patients had minor changes in carbohydrate metabolism, and their immunoreactive insulin levels did not increase with hyperglycemia and arginine administration. One had elevated basal levels of free fatty acids; in both the levels rose on fasting. During short-term metabolic studies exogenously administered human growth hormone did not reduce urinary nitrogen excretion or raise urinary calcium and hydroxyproline excretion. Growth hormone for six months failed to increase their linear growth velocity.