INFLUENCE OF TEMPERATURE ON INHIBITION OF MICROCOCCUS PYOGENES BY CHLORAMPHENICOL

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Abstract
The growth of a sensitive and a resistant strain of M. pyogenes was determined at temperatures ranging from 25[degree] to 42[degree]C in the presence and absence of chloramphenicol. The optimal temperature for growth of both strains, both with and without the antibiotic, is 37[degree]C. Deviation from this temperature enhances the inhibitory activity of chloramphenicol, confirming earlier conclusions that maximal resistance to chloramphenicol is obtained under conditions which favor high metabolic activity.