Electroencephalographic and Behavioral Effects of a GABA Agonist (Muscimol) on Photosensitive Epilepsy in the Baboon, Papio papio
- 1 August 1979
- Vol. 20 (4) , 409-416
- https://doi.org/10.1111/j.1528-1157.1979.tb04821.x
Abstract
Muscimol, 0.25-1.0 mg/kg, i.v., was administered acutely to 4 adolescent baboons, P. papio, that show photically induced epilepsy. On the EEG, slowing of background rhythms was associated with the appearance of spikes, polyspikes and recurring symmetrical spike-wave complexes. These changes were maximal 0.5-2 h after muscimol injection. Regular testing with intermittent light stimulation showed either no change from control responses or a more severe epileptiform EEG 0.1-3 h after muscimol. Photically induced myoclonus was not modified by muscimol. Despite its GABA-agonist properties, muscimol is not an effective anticonvulsant.Keywords
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