Studies in hyperkinetic behavior

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Abstract
The effects of methylphenldate, amphetamine, dlphenylhydantoln, dimethadione, and phenobarbltal on locomotor activity were studied in mice, and the responses to methylphenldate and phenobarbltal were compared in children with various neurologic disorders. Methylphenidate and amphetamine increased activity in mice, and acute doses of methylphenidate increased activity in 4 children. Diphenylhydantoin and dimethadione in nontoxic doses suppressed locomotor activity in mice. Phenobarbital caused suppression of activity in 2 children and in mice. Some doses caused a significant stimulation of activity in mice. A small increase in activity in 3 children was not significantly different from a placebo effect.

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