OBTENTION DE β-HYDROXYPHOSTONES PAR THERMOLYSE DES DIHYDROXY-2,3 ALKYL PHOSPHONATES DE DIALKYLE. ETUDES STEREOCHIMIQUES PAR RMN DU1H,31P ET13C
- 1 March 1988
- journal article
- research article
- Published by Taylor & Francis in Phosphorus and Sulfur and the Related Elements
- Vol. 36 (1) , 39-52
- https://doi.org/10.1080/03086648808078996
Abstract
Novel phosphorus heterocycles, 2-ethoxy-2-oxo-4-hydroxy-1,2-oxaphospholanes, that we have named “β-hydroxyphostones”, have been prepared by thermal intramolecular cyclisation in refluxing dimethyl formamide of 2,3-dihydroxyalkyl diethyl phosphonates. Both diastereomers A and B were so obtained in equimolar amounts with good yields. The stereochemistry of these β-hydroxyphostones was assigned from 1H and 13C NMR data. Possible conformations deduced from 3 J PCCH and 3 J POCC coupling constants were also proposed.Keywords
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