Rapid determination of trichloroethanol and trichloroacetic acid in urine

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Abstract
Trichloroethanol and trichloroacetic acid are determined in the same aliquot of urine by use of a simple spectrophotometric technique. The method is based on the Fujiwara reaction, i.e., the reaction between organic halides and pyridine in the presence of sodium hydroxide. Two spectrophotometric measurements are made, one at 530 nm for the determination of trichloroacetic acid, 15 min after colour development, and the other at 367 nm for the determination of total trichloro compounds and trichlorethanol, 3 h after colour development. The method is rapid and accurate and is therefore suitable for monitoring patients with trichloroethylene and chloral hydrate poisoning.

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