INTERACTIONS OF GASTRIC BLOOD-FLOW, BARRIER BREAKER, AND HYDROGEN-ION BACK DIFFUSION DURING ULCER FORMATION IN RAT

  • 1 January 1978
    • journal article
    • research article
    • Vol. 83  (3) , 248-251
Abstract
A rat gastric chamber preparation was used to determine the interrelations between H+ back diffusion, mucosal blood flow, the area of mucosa treated with bile salts and ulcer formation. The rate of H+ back diffusion was dependent on mucosal blood flow and the area of mucosa exposed to bile salts. Although H+ back diffusion is a convenient measure of barrier premeability under conditions of normal mucosal blood flow, during mucosal ischemia this parameter failed to reflect permeability because of decreased mucosal clearance of H+. Apparent controversy whereby ulceration occurs under shock conditions in the absence of apparent H+ back diffusion is explained.

This publication has 0 references indexed in Scilit: