A process is described for the fabrication of CMOS integrated circuits which combines the epitaxial lateral overgrowth (ELO) technique with the concept of selective epitaxy. The resulting epitaxial material is shown to have a low defect density. Transistors fabricated in the selective epitaxy are shown to have characteristics which are a function of the epitaxial deposition conditions, the substrate orientation and dopant concentration, and the epitaxial layer thickness. Minimum device leakage currents were 250 pA/µm of channel width for n-channel devices fabricated in a p-well and 1.0 pA/µm for devices fabricated on p-substrates. The higher leakage currents for devices fabricated in a well are believed to be a result of the narrow vertical spacing (0.3-0.5 µm) between the n+source-drain regions and the n+substrate.