Flexible regression models with cubic splines
- 1 May 1989
- journal article
- research article
- Published by Wiley in Statistics in Medicine
- Vol. 8 (5) , 551-561
- https://doi.org/10.1002/sim.4780080504
Abstract
We describe the use of cubic splines in regression models to represent the relationship between the response variable and a vector of covariates. This simple method can help prevent the problems that result from inappropriate linearity assumptions. We compare restricted cubic spline regression to non‐parametric procedures for characterizing the relationship between age and survival in the Stanford Heart Transplant data. We also provide an illustrative example in cancer therapeutics.Keywords
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