Assessment of free light chains in the cerebrospinal fluid of patients with lymphomatous meningitis – a pilot study
Open Access
- 3 October 2007
- journal article
- Published by Springer Nature in BMC Cancer
- Vol. 7 (1) , 185
- https://doi.org/10.1186/1471-2407-7-185
Abstract
Lymphomatous meningitis (LM) represents a severe complication of malignant lymphomas. While clinical suspicion is raised by symptoms ranging from mild disturbances of sensation to severe pain or impaired consciousness, the definite diagnosis of LM is often difficult to obtain. Since B-cell lymphomas are clonally restricted to express either kappa or lambda immunoglobulin light chain, we hypothesised that analysis of free light chain (FLC) ratios might facilitate the diagnosis of LM.Keywords
This publication has 24 references indexed in Scilit:
- The tumor kinetics of multiple myeloma following autologous stem cell transplantation as assessed by measuring serum-free light chainsLeukemia & Lymphoma, 2006
- Doxorubicin and dexamethasone followed by thalidomide and dexamethasone is an effective well tolerated initial therapy for multiple myelomaBritish Journal of Haematology, 2005
- Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significanceBlood, 2005
- Kappa Free Light Chains in Cerebrospinal Fluid as Markers of Intrathecal Immunoglobulin SynthesisClinical Chemistry, 2004
- Clinical follow‐up indicates differential accuracy of magnetic resonance imaging and immunocytology of the cerebral spinal fluid for the diagnosis of neoplastic meningitis – a single centre experienceBritish Journal of Haematology, 2004
- Quantitative Analysis of Serum Free Light ChainsAmerican Journal of Clinical Pathology, 2003
- Viral MeningitisSeminars in Neurology, 2000
- Acute Bacterial MeningitisSeminars in Neurology, 2000
- Secondary central nervous system involvement by non‐Hodgkin's lymphoma: The risk factorsHematological Oncology, 1990
- CNS involvement in the non-hodgkin's lymphomasCancer, 1980