Electrochemical processes in a wire-in-a-capillary bulk-loaded, nano-electrospray emitter
- 1 July 2001
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Society for Mass Spectrometry
- Vol. 12 (7) , 853-862
- https://doi.org/10.1016/s1044-0305(01)00264-1
Abstract
Experiments are described that illustrate solvent oxidation, emitter electrode corrosion, and analyte oxidation in positive ion mode nano-electrospray mass spectrometry using a wire-in-a-capillary, bulk-loaded nano-electrospray emitter geometry. Time-lapsed color photography of pH and metal specific indicator solutions within operating nano-electrospray emitters, as well as temporal changes in the ions observed in the nano-electrospray mass spectra, are used to probe these reactions, judge their magnitude, and study the time dependent changes in solution composition and gas-phase ion signal brought about as a result of these electrochemical reactions. The significance of these observations for analytical applications of nano-electrospray mass spectrometry are discussed.Keywords
This publication has 31 references indexed in Scilit:
- Electrolytic deposition of metals on to the high-voltage contact in an electrospray emitter: implications for gas-phase ion formationJournal of Mass Spectrometry, 2000
- Quantitative electrospray ionization mass spectrometric studies of ternary complexes of amino acids with Cu2+ and phenanthrolineJournal of Mass Spectrometry, 2000
- Computational Simulation of Redox Reactions within a Metal Electrospray EmitterAnalytical Chemistry, 1999
- Coordination-Ionspray-MS (CIS-MS), a Universal Detection and Characterization Method for Direct Coupling with Separation TechniquesAngewandte Chemie International Edition in English, 1999
- Electrolytic corrosion of a stainless-steel electrospray emitter monitored using an electrospray–photodiode array systemJournal of Analytical Atomic Spectrometry, 1998
- Changes in bulk solution pH caused by the inherent controlled-current electrolytic process of an electrospray ion sourceInternational Journal of Mass Spectrometry and Ion Processes, 1997
- Analytical Properties of the Nanoelectrospray Ion SourceAnalytical Chemistry, 1996
- Durable Gold-Coated Fused Silica Capillaries for Use in Electrospray Mass SpectrometryAnalytical Chemistry, 1995
- Electrospray and Taylor-Cone theory, Dole's beam of macromolecules at last?International Journal of Mass Spectrometry and Ion Processes, 1994
- From ions in solution to ions in the gas phase - the mechanism of electrospray mass spectrometryAnalytical Chemistry, 1993