Immunopotentiation with BCG. III. Modulation of the Response to a Tumor-Specific Antigen 2

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Abstract
A mouse model was developed for study of the effect of BCG on the induction of systemic immunity to the DBA/2 mastocytoma, P815 (MA), in (C57BL/6 × DBA/2)F1 female mice. Two conventional tests, implantation and subsequent excision of living tumor cells and immunization with irradiated tumor cells, showed the MA had no detectable immunogenicity. However, a small inoculum grew in the footpad for only a limited period and then regressed. This incipient immunogenicity was more apparent when a varying number of BCG was added to the tumor inoculum; the survivors, however, were not uniformly immune to challenge. When irradiated MA cells were injected into sites prepared by a prior injection of BCG, a varying degree of immunity developed against a large tumor challenge (106 MA) at a distant site in the footpad. Resistance was not discernibly increased by BCG or irradiated MA alone, but the combined stimulus suppressed a tumor challenge in all mice for 10 days. Tumors subsequently “escaped” over a period of 50 days in 5 of 6 mice; but 5 of 6 tumor-free survivors from other experiments were resistant to 106 MA when challenged after 100 days.

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