STREPTOMYCIN TREATMENT OF BACTERIAL ENDOCARDITIS DUE TO STREPTOCOCCUS VIRIDANS; REPORT OF TWO CASES

1 May 1949

journal article
research article
Published by American College of Physicians in Annals of Internal Medicine

Vol. 30 (5) , 1049-1053
https://doi.org/10.7326/0003-4819-30-5-1049

Abstract

Streptomycin was successfully used in the treatment of two cases of bacterial endocarditis caused by typical Streptococcus viridans. The causative organism was isolated in each case and detd. to be insensitive in vitro to serum penicillin levels of 10 and 5 U./ml. resp., but sensitive to streptomycin concns. of 8 and 16 U./ml. The concn. of streptomycin maintained in the blood ranged from 2.5-5x that required to inhibit the organism in vitro, and clinical cure resulted.

Keywords

This publication has 3 references indexed in Scilit:

PENICILLIN THERAPY OF SUBACUTE BACTERIAL ENDOCARDITIS
Archives of internal medicine (1960), 1947
STREPTOMYCIN IN THE TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS
JAMA, 1946
THE TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS WITH PENICILLIN: SECOND REPORT
Annals of Internal Medicine, 1946