Mechanisms of group B coxsackie virus persistence in human cells

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Abstract
Group B coxsackie viruses (CVB) readily establish persistent infections in human lymphoidcell lines. CVB3 persistence in the T cell line MOLT-4 was maintained by viral replication in a small fraction of the cells at any given time and appeared to be due to the continuous emergence of a few susceptible cells among a population of otherwise resistant cells. Chronic infection was terminated by CVB3-specific antibody and interferon (IFN). This experimental model may be useful in elucidating how CVBs are implicated in the genesis of chronic myocardiopathies.

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