Highly diastereofacial selective addition of nucleophiles to 2-alkyl-3-trimethylsilyl alk-3-enyl carbonyl compounds. Stereoselective preparation of β-methylhomoallyl alcohols and β-hydroxy-α-methyl ketones
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 16,p. 1130-1132
- https://doi.org/10.1039/c39840001130
Abstract
Nucleophiles react with 2-alkyl-3-trimethylsilylalk-3-enyl carbonyl compounds to afford ‘Cram’ products with high diastereoselectivity; this allows the stereoselective preparation of β-methylhomoally alcohols and β-hydroxy-α-methyl ketones.Keywords
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