High Performance Liquid Chromatographic Analysis of Cepoperazone in Serum and Urine
- 1 October 1984
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 7 (12) , 2421-2429
- https://doi.org/10.1080/01483918408068887
Abstract
A high performance liquid chromatographic method was developed for the quantitative analysis of cefoperazone in serum and urine. Standard curves were linear over the range of concentrations 2–30 μg/ml and a good correlation was established between the amount of cefoperazone injected and peak height. The mean percentage analytical recovery of cefoperazone was 96.3% and the mean within day coefficient of variation in serum was 2.8%. Serum and urine components, as well as several beta-lactam antibiotics, did not interfere with the measurement of cefoperazone. This is a rapid, reproducible, and sensitive assay suitable for use in pharmacokinetic studies.This publication has 4 references indexed in Scilit:
- Cefoperazone pharmacokinetics in normal subjects and patients with cirrhosisAntimicrobial Agents and Chemotherapy, 1983
- High performance liquid chromatographic determination of cefoperazone in human serum and urineJournal of Chromatography B: Biomedical Sciences and Applications, 1983
- Determination of cephalosporins in biological material by reversed-phase liquid column chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1981
- High-Performance Liquid Chromatographic Determination of Cefoperazone in SerumJournal of Liquid Chromatography, 1981