PERMEABILITY OF NORMAL AND INJURED SKIN CAPILLARIES TO LIPOPROTEINS IN THE RABBIT

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Abstract
SUMMARY: Lymph was collected from the hind paws of rabbits in different types of lipaemia. Hyper‐cholesterolaemia was induced by adding cholesterol to the diet and hyperlipaemia by the intravenous injection of Triton WR‐1339.In these conditions the lipids in the lymph from the hind paw were present as all the lipoprotein complexes, including lipid particles, of the plasma in average concentrations of about 20 p.c. of the plasma levels.When the skin capillaries were injured by scalding the paw, the lymph became quite milky in appearance when the plasma was milky. After the intravenous infusion of an artificial fat emulsion in which the lipid particles were about 1 μ in diameter, there was only a relatively small increase in these particles in the lymph, which macroscopically remained clear.The possible mechanisms of transfer of these lipids across the capillary endothelium are discussed.

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