RADIOIODINATED BRETYLIUM ANALOG AS A POTENTIAL AGENT FOR SCANNING ADRENAL-MEDULLA

  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (1) , 87-89
Abstract
Studies with radioiodinated bretylium analogs (RIBA) suggested that the p-isomer was capable of concentrating in adrenal medulla. The present studies with 125I-p-RIBA in rats and dogs confirm this property and show its marked and persistent affinity for the adrenal medulla. Analogous studies with 14C-p-IBA indicate that it is the quaternary form of the drug that is retained by the adrenal and that high thyroidal radioactivity following 125I-p-RIBA administration is due to in vivo deiodination of the drug.

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