The scanning model for translation: an update.
Open Access
- 1 February 1989
- journal article
- review article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 108 (2) , 229-241
- https://doi.org/10.1083/jcb.108.2.229
Abstract
The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation. The first-AUG rule is not absolute, but there are rules for breaking the rule. Some anomalous observations that seemed to contradict the scanning mechanism now appear to be artifacts. A few genuine anomalies remain unexplained.Keywords
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